Plasma proteomic analysis in male normotensive, prehypertensive and hypertensive subjects / 中华心血管病杂志
Chinese Journal of Cardiology
;
(12): 5-10, 2010.
Artículo
en Chino
| WPRIM
| ID: wpr-323888
ABSTRACT
<p><b>OBJECTIVE</b>To compare the plasma proteome among male normotensive, prehypertensive, and hypertensive subjects.</p><p><b>METHODS</b>Plasma proteome was analyzed by two-dimensional electrophoresis combined with MALDI-TOF mass spectrometry in this case-control study among well matched male normotensive, prehypertensive and hypertensive subjects (n = 26 each).</p><p><b>RESULTS</b>The results showed that there were 22 differentially expressed protein spots among the protein samples derived from the 3 groups which corresponded to 18 proteins associated with inflammation and immunity, lipid metabolism, transport, coagulation and fibrinolysis, cell proliferation and apoptosis, and antioxidation.</p><p><b>CONCLUSION</b>Proteins were differentially expressed in male subjects with various blood pressure levels.</p>
Texto completo:
Disponible
Índice:
WPRIM (Pacífico Occidental)
Asunto principal:
Presión Sanguínea
/
Estudios de Casos y Controles
/
Espectrometría de Masa por Láser de Matriz Asistida de Ionización Desorción
/
Proteómica
/
Prehipertensión
/
Genética
/
Hipertensión
Tipo de estudio:
Estudio observacional
/
Factores de riesgo
Límite:
Adulto
/
Humanos
/
Masculino
Idioma:
Chino
Revista:
Chinese Journal of Cardiology
Año:
2010
Tipo del documento:
Artículo
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