Expression of a disintegrin-like and metalloproteinase protein 8 and 12 in the giant cell lesions of jaw / 中华口腔医学杂志
Chinese Journal of Stomatology
;
(12): 294-297, 2004.
Artículo
en Chino
| WPRIM
| ID: wpr-324167
ABSTRACT
<p><b>OBJECTIVE</b>To detect the expression of a disintegrin-like and metalloproteinase (ADAM) 8 and 12 gene in the giant cell lesions of jaw and to study their effects on the histogenesis of cells in these lesions.</p><p><b>METHODS</b>ADAM8 and ADAM12 was detected by immunohistochemistry (SP) in 40 paraffin-embedded specimens of central giant cell lesions of jaw, 10 peripheral giant cell lesions, 9 cherubisms, 6 aneurysmal bone cysts.</p><p><b>RESULTS</b>ADAM8 and ADAM12 were positive in the cytomembrane and cytoplasm of all multinucleated giant cells and some round mononuclear cells of the lesions; ADAM12 was positive for some spindle mononuclear stromal cells in central and peripheral giant cell lesions.</p><p><b>CONCLUSIONS</b>Multinucleated giant cells probably originated from the fusion of the round mononuclear cells, and ADAM8 and ADAM12 were involved in this process. In addition, ADAM12 might play a role in the maturation of spindle mononuclear stromal cells.</p>
Texto completo:
Disponible
Índice:
WPRIM (Pacífico Occidental)
Asunto principal:
Metaloendopeptidasas
/
Neoplasias Maxilomandibulares
/
Neoplasias Maxilares
/
Antígenos CD
/
Tumor Óseo de Células Gigantes
/
Proteínas ADAM
/
Proteína ADAM12
/
Genética
/
Proteínas de la Membrana
/
Metabolismo
Límite:
Humanos
Idioma:
Chino
Revista:
Chinese Journal of Stomatology
Año:
2004
Tipo del documento:
Artículo
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