Diagnosis of Cowden's Disease Based on Gastrointestinal Manifestations / 대한소화기내시경학회지
Korean Journal of Gastrointestinal Endoscopy
;
: 183-191, 2003.
Artículo
en Coreano
| WPRIM
| ID: wpr-32425
ABSTRACT
BACKGROUND/AIMS:
Cowden's disease is an autosomal dominant hereditary disease characterized by the various hamartomatous and neoplastic lesions of multiple organs. We analyzed gastrointestinal manifestations of 5 cases of Cowden's disease and suggest several findings which are helpful to gastroenterologists for the early diagnosis.METHODS:
The clinical characteristics of 5 unrelated patients with Cowden's disease were evaluated. Four patients were male, one patient was female, and their ages at the time diagnosis ranged from 17 to 49 years. All patients had the pathognomonic mucocutaneous lesions and thyroid nodules.RESULTS:
In all patients, the esophagus was affected by acanthosis. In 4 patients, the stomach was affected by numerous variable sized polyps. In 4 patients, the duodenum was involved by several polyps. In 4 patients, the entire small bowel and in one patients, only the terminal ileum was affected by numerous polyps. In all patients, the colon, especially the sigmoid colon and rectum, showed numerous variable sized polyps. Family history was positive for stomach cancer in two patients.CONCLUSIONS:
Cowden's disease should be considered in patients with esophageal acanthosis among patients with colonic polyposis, although the mucocutaneous lesions, unfamiliar to gastroenterolgists, are pathognomonic criteria for the diagnosis.
Texto completo:
Disponible
Índice:
WPRIM (Pacífico Occidental)
Asunto principal:
Pólipos
/
Recto
/
Colon Sigmoide
/
Estómago
/
Neoplasias Gástricas
/
Síndrome de Hamartoma Múltiple
/
Nódulo Tiroideo
/
Colon
/
Diagnóstico Precoz
/
Diagnóstico
Tipo de estudio:
Estudio diagnóstico
/
Estudio de tamizaje
Límite:
Femenino
/
Humanos
/
Masculino
Idioma:
Coreano
Revista:
Korean Journal of Gastrointestinal Endoscopy
Año:
2003
Tipo del documento:
Artículo
Similares
MEDLINE
...
LILACS
LIS