Studies on separation, appraisal and the biological activity of 5-HMF in Cornus officinalis / 中国中药杂志

ABSTRACT

<p><b>OBJECTIVE</b>To develop the mechanism of improving protection function of prepared Cornus officinalis for liver and kidney and the biological activity of 5-hydroxymethylfurfural (5-HMF).</p><p><b>METHOD</b>Pharmacological and chemical studies were used to choose active part. A compound from active part was separated and appraised. To investigate his biological functions, pharmacological experiment was actualized.</p><p><b>RESULT</b>A component was separated and identified. His is 5-HMF. 5-HMF can protect human vein epidermal cell against H2O2 and glucose and inprove acute liver injury in mice.</p><p><b>CONCLUSION</b>5-HMF is the active component in prepared Cornus officinalis and substance basis for protecting liver and kidney.</p>