The potential role of IGF-I receptor mRNA in rats with diabetic retinopathy / 中华医学杂志(英文版)
Chinese Medical Journal
;
(24): 478-480, 2003.
Artículo
en Inglés
| WPRIM
| ID: wpr-324445
ABSTRACT
<p><b>OBJECTIVE</b>To evaluate the potential role of insulin-like growth factor-1 receptor mRNA (IGF-IR mRNA) in the onset and development of retinopathy in diabetic rats.</p><p><b>METHODS</b>A diabetic model was duplicated in Wistar rats. The early changes in the retina were examined using light and transmission electron microscopy. Expression of IGF-IR mRNA was analyzed using in situ hybridization.</p><p><b>RESULTS</b>Weak expression of IGF-IR mRNA (5%) was found in retinas of normal rats, but was significantly increased (15% and 18%) in the retinas of diabetic rats after 3 and 6 months of diabetes (P < 0.01). In situ hybridization and morphological study demonstrated that there was a positive correlation between IGF-IR mRNA expression and retinal changes at various stages.</p><p><b>CONCLUSION</b>Increased IGF-IR mRNA might play an important role in the onset and development of diabetic retinopathy.</p>
Texto completo:
Disponible
Índice:
WPRIM (Pacífico Occidental)
Asunto principal:
Patología
/
Fisiología
/
Retina
/
Glucemia
/
Hemoglobina Glucada
/
ARN Mensajero
/
Factor I del Crecimiento Similar a la Insulina
/
Receptor IGF Tipo 1
/
Ratas Wistar
/
Retinopatía Diabética
Tipo de estudio:
Estudio pronóstico
Límite:
Animales
Idioma:
Inglés
Revista:
Chinese Medical Journal
Año:
2003
Tipo del documento:
Artículo
Similares
MEDLINE
...
LILACS
LIS