The role of CTLA4-Ig in a mouse model against allergic asthma / 中华医学杂志(英文版)

ABSTRACT

<p><b>OBJECTIVE</b>To investigate CTLA4-Ig's potential role in therapy for allergic asthma by blocking B7/CD28 interactions with cytotoxic T lymphocyte antigen 4-Ig (CTLA4-Ig).</p><p><b>METHODS</b>We divided BALB/C mice into the three groups Sham/Sham (control), ovalbumin (OVA)/OVA and mCTLA4-Ig. Blood, bronchoalveolar lavage, histology and determination of cytokines were performed 24 hours after airway challenge.</p><p><b>RESULTS</b>In the OVA/OVA group, the number of cells, the percentage of inflamed cells and the level of IL-4 in BALF were increased. Airways in our murine model for allergic asthma underwent pathological changes, which were significantly reduced after treatment with mCTLA4-Ig.</p><p><b>CONCLUSION</b>Blockage of co-stimulation with mCTLA4-Ig can inhibit allergy-specific response of T cells, and asthmatic response as well.</p>