Capsid assembly and DNA encapsidation of adeno-associated virus / 生物工程学报
Chinese Journal of Biotechnology
;
(12): 531-538, 2011.
Artículo
en Chino
| WPRIM
| ID: wpr-324532
ABSTRACT
Recombinant adeno-associated viral vectors (rAAV) have been widely used as gene therapy vectors in clinical trials. Here, we reviewed the genomic structures and replication mechanisms of wt-AAV. Then, the assembly of capsid and the encapsidation of genomic DNA, two major events during AAV pakaging, was discussed in detail. Although the overall pattern of virus assembly and encapsidation is known, the molecular mechanisms and the structure-function relationship involved in these processes are not well understood. Further elucidatation of these processes may improve the production technology of rAAV and develop gene drug based on rAAV.
Texto completo:
Disponible
Índice:
WPRIM (Pacífico Occidental)
Asunto principal:
Fisiología
/
ADN Viral
/
Cápside
/
Genoma Viral
/
Dependovirus
/
Ensamble de Virus
/
Proteínas de la Cápside
/
Vectores Genéticos
/
Genética
Idioma:
Chino
Revista:
Chinese Journal of Biotechnology
Año:
2011
Tipo del documento:
Artículo
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