Study on fingerprints correlated with pharmacodynamic of Paeonia lacliflora and Glycyrrhiza uralensis effective compounds / 中国中药杂志
China Journal of Chinese Materia Medica
;
(24): 2658-2662, 2008.
Artículo
en Chino
| WPRIM
| ID: wpr-324830
ABSTRACT
<p><b>OBJECTIVE</b>To study the spasmolysisy activity constituents of the Radix Paeoniae alba and Radix et Rhizoma compound.</p><p><b>METHOD</b>The three effective compounds of Radix Paeoniae and Radix et Rhizoma were arrayed to eight groups by orthogonal design rat, serum samples were collected after administered in these groups, and these serum samples were used to carry out the experiments of serum pharmacology of spasmolysis. The inhibition ratios were assigned as pharmacodynamic variable X, the areas of characteristic peaks on HPLC fingerprints were assigned as variable Y, and the correlation of X and Y was studied in order to research the activity spasmolysisy compounds of effective constituents. Serum samples were analyzed by HPLC-ESI-MS/MS.</p><p><b>RESULT</b>The correlation of fingerprints and pharmacology showed that four compounds were the main spasmolysisy activity compounds. The correlation parameter was greater than >0.4, whose value were 0.774, 0.678, 0.566 and 0.472 respectively, and their retention times were 8.03, 51.7, 54.59 and 72.43 min respectively. They were metabolites of effective compounds.</p><p><b>CONCLUSION</b>This study makes a valid approach for understanding the material foundation of TCM by establishing the correlation of fingerprints and pharmacology of activity compounds in vivo.</p>
Texto completo:
Disponible
Índice:
WPRIM (Pacífico Occidental)
Asunto principal:
Farmacología
/
Medicamentos Herbarios Chinos
/
Farmacocinética
/
Química
/
Cromatografía Líquida de Alta Presión
/
Espectrometría de Masa por Ionización de Electrospray
/
Glycyrrhiza uralensis
/
Paeonia
/
Espectrometría de Masas en Tándem
/
Contracción Muscular
Límite:
Animales
Idioma:
Chino
Revista:
China Journal of Chinese Materia Medica
Año:
2008
Tipo del documento:
Artículo
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