Effect of jinfu kang to experimental precancerous colon lesions and urinary metabolites in rat / 中国中药杂志
China Journal of Chinese Materia Medica
; (24): 2653-2657, 2008.
Article
en Zh
| WPRIM
| ID: wpr-324831
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WPRO
ABSTRACT
<p><b>OBJECTIVE</b>: To profile urinary metabolite variations from 1, 2-dimethylhydrazine (DMH)-induced precancerous colon rats, Jinfu Kang treated rats and healthy controls.</p><p><b>METHOD</b>We used ethyl chloroformate derivatization and gas chromatography-mass spectrometry (GC-MS) based metabonomic method to analyze rat urines.</p><p><b>RESULT</b>The time-dependent variations of metabolite profile showed a progressive deviation of the metabolism in the model group from the initial pattern over time and a systemic recovery of the metabolism in the treatment group, which is consistent with the histological results. The in-depth analysis indicated that the disorder of tricarboxylic acid cycle (TCA), tryptophan metabolism, polyamine metabolism and gut flora structure were associated with DMH intervention.</p><p><b>CONCLUSION</b>Metabolic study revealed that Jinfu Kang can effectively reverse metabolic departures in DMH-induced precancerous colon rat, which is consistent with pathological results.</p>
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Asunto principal:
Patología
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Farmacología
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Orina
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Medicamentos Herbarios Chinos
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Pólipos del Colon
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Ratas Wistar
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Neoplasias del Colon
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Dimetilhidrazinas
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Quimioterapia
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Cromatografía de Gases y Espectrometría de Masas
Límite:
Animals
Idioma:
Zh
Revista:
China Journal of Chinese Materia Medica
Año:
2008
Tipo del documento:
Article