Effects of laparoscopic surgery on the immune system of the patients with gynecologic diseases / 대한산부인과학회지
Korean Journal of Obstetrics and Gynecology
;
: 776-783, 2007.
Artículo
en Coreano
| WPRIM
| ID: wpr-32486
ABSTRACT
OBJECTIVE:
Elective surgical approaches and trauma cause changes in the production of different cytokines. The aim of this study was to evaluate the effects of laparoscopic surgery on the immune system of patients with gynecologic diseases.METHODS:
We recruited the open surgery group (n=20) and laparoscopic surgery group (n=33). In a prospective study we examined the C-reactive protein (CRP) level, the production of the cytokines Interleukin-1beta (IL-1beta), Interleukin-6 (IL-6), Interleukin-8 (IL-8), Interleukin-10 (IL-10) and TNF-alpha concentrations by ELISA. In addition the fibrinogen, transferrin, albumin, hemoglobin and hematocrit were measured. Statistical analysis was made by Mann-Whitney U test and Kruskal-Wallis test.RESULTS:
There were significant statistical differences in the CRP, IL-6 and IL-8 between the open surgery group and laparoscopic surgery group after surgery. The CRP and IL-8 showed a more distinct increase in open surgery group 24 hours after surgery, the differences between the two surgical approaches were significant (p<0.05).CONCLUSION:
Elective surgical approaches cause changes in the immune system, which can be evaluated by the reaction of cytokines. Laparoscopic surgery cause less activation of the CRP and IL-8 than open surgery.
Texto completo:
Disponible
Índice:
WPRIM (Pacífico Occidental)
Asunto principal:
Proteína C-Reactiva
/
Fibrinógeno
/
Transferrina
/
Ensayo de Inmunoadsorción Enzimática
/
Estudios Prospectivos
/
Citocinas
/
Interleucina-8
/
Interleucina-6
/
Factor de Necrosis Tumoral alfa
/
Interleucina-10
Tipo de estudio:
Estudio observacional
Límite:
Femenino
/
Humanos
Idioma:
Coreano
Revista:
Korean Journal of Obstetrics and Gynecology
Año:
2007
Tipo del documento:
Artículo
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