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Cigarette smoking increases levels of retinol-binding protein-4 in healthy men with normal glucose tolerance / 中华医学杂志(英文版)
Chinese Medical Journal ; (24): 1686-1689, 2012.
Artículo en Inglés | WPRIM | ID: wpr-324909
ABSTRACT
<p><b>BACKGROUND</b>Smoking is related with insulin resistance and type 2 diabetes mellitus. Retinol-binding protein-4 is a new adipocytokine associated with insulin resistance. We investigated the serum levels of a series of adipocytokines including retinol-binding protein-4 in smokers and non-smokers to explore the possible roles of adipocytokines on smoking induced insulin resistance.</p><p><b>METHODS</b>A total of 136 healthy male subjects (92 smokers and 44 non-smokers) with normal glucose tolerance were enrolled in the study. Adipocytokines including retinol-binding protein-4, visfatin, leptin, resistin, adiponectin were measured for the comparison between the two groups. Serum lipid profile, glucose, true insulin and proinsulin levels were measured as well in both groups. Food intake spectrum was also investigated.</p><p><b>RESULTS</b>Both groups had similar profile of food consumption; visfatin, leptin, resistin and adiponectin, low-density lipoprotein cholesterol, high-density lipoprotein cholesterol, alanine aminotransferase, aspartate aminotransferase, as well as blood pressure and body mass index, were similar in both groups. Triglycerides, retinol-binding protein-4 and homeostatic model assessment index for insulin resistance were higher in smoker group ((2.58 ± 2.53) vs. (1.60 ± 0.94) mmol/L, (26.05 ± 8.50) vs. (21.83 ± 8.40) µg/ml, and 2.25 ± 2.08 vs. 1.58 ± 1.15, respectively).</p><p><b>CONCLUSION</b>Smoking may have effect on insulin sensitivity, which is correlated with retinol-binding protein-4.</p>
Asunto(s)
Texto completo: Disponible Índice: WPRIM (Pacífico Occidental) Asunto principal: Aspartato Aminotransferasas / Triglicéridos / Sangre / Proteínas de Unión al Retinol / Fumar / Leptina / Alanina Transaminasa / Adiponectina / Resistina / Nicotinamida Fosforribosiltransferasa Tipo de estudio: Estudio pronóstico Límite: Adulto / Humanos / Masculino Idioma: Inglés Revista: Chinese Medical Journal Año: 2012 Tipo del documento: Artículo

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Texto completo: Disponible Índice: WPRIM (Pacífico Occidental) Asunto principal: Aspartato Aminotransferasas / Triglicéridos / Sangre / Proteínas de Unión al Retinol / Fumar / Leptina / Alanina Transaminasa / Adiponectina / Resistina / Nicotinamida Fosforribosiltransferasa Tipo de estudio: Estudio pronóstico Límite: Adulto / Humanos / Masculino Idioma: Inglés Revista: Chinese Medical Journal Año: 2012 Tipo del documento: Artículo