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Genetic association of apoE and apoCI gene polymorphisms with coronary heart disease / 中华流行病学杂志
Chinese Journal of Epidemiology ; (12): 982-985, 2004.
Artículo en Chino | WPRIM | ID: wpr-324976
ABSTRACT
<p><b>OBJECTIVE</b>To study the genetic association of apolipoprotein (apo) E and apoCI gene polymorphisms with coronary heart disease (CHD) in China.</p><p><b>METHODS</b>apoE genotypes were identified by multiplex amplification refractory mutation system (multi-ARMS) and the apoCI promoter polymorphisms were detected by polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) in 186 cases with CHD (age 65.0 +/- 10.5 years) and 350 controls (age 63.6 +/- 8.3 years). The haplotype frequencies were estimated.</p><p><b>RESULTS</b>The frequencies of apoE E4/3 genotype (26.9%) and epsilon4 (14.5%) in CHD group were significantly higher than that in the control group (12.6%, 7.0%), P <0.05. The significant difference was also found for the apoCI locus and the CHD group showed higher rate of both for the H2 allele and genotypes, carrying this allele. Estimation of the haplotype frequencies indicated that the association between the apoE-CI haplotype and CHD was significantly strong. The apoE-epsilon4/apoCI-H2 was estimated to be responsible for 9.86% of CHD.</p><p><b>CONCLUSION</b>When the subjects carrying both epsilon4 and H2 alleles, they would have higher risk of suffering from CHD than controls.</p>
Asunto(s)
Texto completo: Disponible Índice: WPRIM (Pacífico Occidental) Asunto principal: Apolipoproteínas C / Apolipoproteínas E / Sangre / Haplotipos / Polimorfismo de Longitud del Fragmento de Restricción / China / Reacción en Cadena de la Polimerasa / Epidemiología / Factores de Riesgo / Enfermedad Coronaria Tipo de estudio: Estudio de etiología / Estudio pronóstico / Factores de riesgo Límite: Adulto / Anciano / Aged80 / Femenino / Humanos / Masculino País/Región como asunto: Asia Idioma: Chino Revista: Chinese Journal of Epidemiology Año: 2004 Tipo del documento: Artículo

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Texto completo: Disponible Índice: WPRIM (Pacífico Occidental) Asunto principal: Apolipoproteínas C / Apolipoproteínas E / Sangre / Haplotipos / Polimorfismo de Longitud del Fragmento de Restricción / China / Reacción en Cadena de la Polimerasa / Epidemiología / Factores de Riesgo / Enfermedad Coronaria Tipo de estudio: Estudio de etiología / Estudio pronóstico / Factores de riesgo Límite: Adulto / Anciano / Aged80 / Femenino / Humanos / Masculino País/Región como asunto: Asia Idioma: Chino Revista: Chinese Journal of Epidemiology Año: 2004 Tipo del documento: Artículo