Abnormal expression of beta-catenin and E-cadherin in Her2-positive breast cancer and its implications / 南方医科大学学报
Journal of Southern Medical University
;
(12): 2237-2240, 2009.
Artículo
en Chino
| WPRIM
| ID: wpr-325136
ABSTRACT
<p><b>OBJECTIVE</b>To investigate the relationship between positive expression of Her2 and abnormal expressions of beta-catenin and E-cadherin and its implications.</p><p><b>METHODS</b>Immunohistochemistry was used to detect the expressions of Her2, beta-catenin and E-cadherin in 147 samples of human breast carcinoma. The expressions of beta-catenin and E-cadherin were also detected in 19 tissues adjacent to the carcinoma and 17 benign breast lesions as controls.</p><p><b>RESULTS</b>In breast carcinoma, positive Her2 expression was associated with lymph node metastasis, advanced clinical stage and negative expression of ER and PR (P<0.05). Abnormal beta-catenin expression was associated with positive lymph node status and high histological grade (P<0.01). Abnormality of E-cadherin expression was related to lymph node metastasis and advanced clinical stage (P<0.05). Abnormal beta-catenin expression was directly correlated with abnormal E-cadherin expression (P<0.01). Her2 positivity showed a direct correlation to abnormal beta-catenin expression (P<0.01), and they cooperated in promoting axillary lymph node metastasis in human breast carcinoma (P<0.01).</p><p><b>CONCLUSION</b>A direct correlation between positive Her2 expression and abnormal beta-catenin expression exists in human breast carcinoma, and positive Her2 expression may have functional interactions with abnormal activation of Wnt/beta-catenin signaling pathway.</p>
Texto completo:
Disponible
Índice:
WPRIM (Pacífico Occidental)
Asunto principal:
Patología
/
Neoplasias de la Mama
/
Cadherinas
/
Carcinoma Ductal de Mama
/
Receptor ErbB-2
/
Beta Catenina
/
Genética
/
Metástasis Linfática
/
Metabolismo
Límite:
Adulto
/
Anciano
/
Femenino
/
Humanos
Idioma:
Chino
Revista:
Journal of Southern Medical University
Año:
2009
Tipo del documento:
Artículo
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