Expression of transcription factors T-bet and GATA-3 in peripheral blood mononuclear cells from patients with systemic lupus erythematosus / 南方医科大学学报
Journal of Southern Medical University
;
(12): 2138-2139, 2009.
Artículo
en Chino
| WPRIM
| ID: wpr-325162
ABSTRACT
<p><b>OBJECTIVE</b>To investigate the role of transcription factors T-bet and GATA-3 in the pathogenesis of systemic lupus erythematosus (SLE).</p><p><b>METHODS</b>The expression of T-bet and GATA-3 mRNA in the peripheral blood mononuclear cells (PBMCs) of 60 patients with SLE and 20 normal control subjects were detected by reverse transcriptase-polymerase chain reaction (RT-PCR).</p><p><b>RESULTS</b>Compared with the normal controls, T-bet mRNA expression decreased whereas GATA-3 mRNA expression increased significantly in patients with SLE, active SLE and inactive SLE.</p><p><b>CONCLUSIONS</b>The high expression of GATA-3 promotes the immature T cells to differentiate into Th2 cells, induces Th2 cells to secrete the cytokines IL-6 and IL-10, which, along with the low expression of Th1 as a result of T-bet expression inhibition, causes B cell activation to produce a large quantity of autoantibodies, leading finally to multiple organ injuries. Effective regulation of GATA-3 expression may provide a new clue for the treatment of SLE.</p>
Texto completo:
Disponible
Índice:
WPRIM (Pacífico Occidental)
Asunto principal:
Sangre
/
ARN Mensajero
/
Leucocitos Mononucleares
/
Estudios de Casos y Controles
/
Reacción en Cadena de la Polimerasa de Transcriptasa Inversa
/
Proteínas de Dominio T Box
/
Factor de Transcripción GATA3
/
Genética
/
Lupus Eritematoso Sistémico
/
Metabolismo
Tipo de estudio:
Estudio observacional
Límite:
Adolescente
/
Adulto
/
Niño
/
Femenino
/
Humanos
/
Masculino
Idioma:
Chino
Revista:
Journal of Southern Medical University
Año:
2009
Tipo del documento:
Artículo
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