B7-H1, a prognostic factor for patient's response to therapy of acute myeloid leukemia / 中国实验血液学杂志
Journal of Experimental Hematology
; (6): 1332-1335, 2012.
Article
en En
| WPRIM
| ID: wpr-325265
Biblioteca responsable:
WPRO
ABSTRACT
This study was aimed to detect the expression of B7-H1 gene in the acute myeloid leukemia (AML) cells and to explore its clinical significance. The B7-H1 gene expression was detected by real-time quantitative PCR in bone marrow mononuclear cells (BMMNC) from 40 newly diagnosed AML patients, 10 normal volunteers and 10 relapsed patients. The results showed that the expression of B7-H1 from de novo AML patients was lower than that from the normal volunteers, but it was higher in the relapsed patients. The expression level of B7-H1 gene before therapy was significantly higher in non CR patients than that in CR patients after therapy. It is concluded that there is a correlation between the expression level of B7-H1 gene and response to therapy.
Texto completo:
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Índice:
WPRIM
Asunto principal:
Pronóstico
/
Recurrencia
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ARN Mensajero
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Leucemia Mieloide Aguda
/
Estudios de Casos y Controles
/
Expresión Génica
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Reacción en Cadena de la Polimerasa de Transcriptasa Inversa
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Diagnóstico
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Antígeno B7-H1
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Genética
Tipo de estudio:
Diagnostic_studies
/
Observational_studies
/
Prognostic_studies
Límite:
Adolescent
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Adult
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Aged
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Female
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Humans
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Male
Idioma:
En
Revista:
Journal of Experimental Hematology
Año:
2012
Tipo del documento:
Article