Preliminary study on genotype of hepatitis B virus detected from Xinjiang Uygur Autonomous Region in China / 中华实验和临床病毒学杂志

ABSTRACT

<p><b>OBJECTIVE</b>To determine the main genotype of hepatitis B virus (HBV) in Xinjiang.</p><p><b>METHODS</b>200 HBsAg positive serum specimens were detected from more than 2000 serum of Xinjiang inhabitants, and HBV S gene was detected by using nPCR amplifying, and compared with the standard S region HBV nucleotide sequences of genotypes A-H retrieved from GenBank, then analyzed and drawn the polygenetic tree by MEGA3 software.</p><p><b>RESULT</b>Gene in 127 (63.5%) serum specimens was detected from 200 samples. Among 127 serum specimens, 10 (7.8%) was genotype B, 58 (45.7%) was genotype C, and 59 (46.5%) was genotype D.</p><p><b>CONCLUSION</b>Genotype B, C and D have been found in Xinjiang.</p>