Bioactive Constituents from the Leaves of Zanthoxylum schinifolium
Natural Product Sciences
;
: 1-5, 2015.
Artículo
en Inglés
| WPRIM
| ID: wpr-32663
ABSTRACT
Activity-guided separation of the methylene chloride-soluble fraction of the leaves of Zanthoxylum schinifolium, resulted in the isolation of four coumarinoids (1 - 4), two triterpenoids (5, 6) and three fatty acid derivatives (7 - 9) as active principles. Their chemical structures were identified as collinin (1), 8-methoxyanisocoumarin (2), 7-(6'R-hydroxy-3',7'-dimethylocta-2',7'-dienyloxy)-coumarin (3), (E)-4-methly-6-(coumarin-7'-yloxy) hex-4-enal (4), lupeol (5), epi-lupeol (6), phytol (7), hexadec-3-enoic acid (8) and palmitic acid (9), on the basis of spectroscopic (1D, 2D and MS) data analyses and comparing with the data published in the literatures. Compounds 1 and 7 showed potent cytotoxicity against Jurkat T cells with IC50 values of 45.58 and 47.51 microM, respectively. The others showed moderate activity with IC50 values ranging around 80.58 to 85.83 microM, while the positive control, auraptene, possessed an IC50 value of 55.36 microM.
Texto completo:
Disponible
Índice:
WPRIM (Pacífico Occidental)
Asunto principal:
Fitol
/
Linfocitos T
/
Estadística como Asunto
/
Ácido Palmítico
/
Concentración 50 Inhibidora
/
Rutaceae
/
Zanthoxylum
Idioma:
Inglés
Revista:
Natural Product Sciences
Año:
2015
Tipo del documento:
Artículo
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