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Pressure-induced expression of immediate-early gene product c-Jun of the common carotid arteries in rats / 生物医学工程学杂志
Journal of Biomedical Engineering ; (6): 35-37, 2005.
Artículo en Chino | WPRIM | ID: wpr-327140
ABSTRACT
In order to investigate the mechanism of mechanical stress-mediated arterial remodeling, we studied the pressure-induced expression of immediate-early response gene product c-Jun in common carotid arteries in rats. The common carotid arteries were perfused with both high pressure (160 mmHg) and normal pressure (80 mmHg) for 0.5, 1, 3 and 6 hours. Expression of immediate-early response gene product c-Jun in the arteries was examined by immunohistochemistry and computer image processing. c-Jun was weakly expressed at 1 h, then increased at 3 h and 6 h after exposure of the arteries to normal pressure. Positive immunohistochemical product of c-Jun appeared in the arteries at 0.5 h after the onset of high pressure, then it increased markedly till 6 h. There was significant difference between the two groups. These results indicate that expression of c-Jun of the arteries can be induced by pressure, which may play an important role in mechanical stress-mediated arterial remodeling.
Asunto(s)
Texto completo: Disponible Índice: WPRIM (Pacífico Occidental) Asunto principal: Fisiología / Presión / Estrés Mecánico / Fenómenos Biomecánicos / Proteínas Proto-Oncogénicas c-jun / Ratas Sprague-Dawley / Arteria Carótida Común / Genes Inmediatos-Precoces / Biología Celular / Genética Límite: Animales Idioma: Chino Revista: Journal of Biomedical Engineering Año: 2005 Tipo del documento: Artículo

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Texto completo: Disponible Índice: WPRIM (Pacífico Occidental) Asunto principal: Fisiología / Presión / Estrés Mecánico / Fenómenos Biomecánicos / Proteínas Proto-Oncogénicas c-jun / Ratas Sprague-Dawley / Arteria Carótida Común / Genes Inmediatos-Precoces / Biología Celular / Genética Límite: Animales Idioma: Chino Revista: Journal of Biomedical Engineering Año: 2005 Tipo del documento: Artículo