The correlation between the expansion volume and the contents of b-FGF and EGF in the expanded skin / 中华整形外科杂志

ABSTRACT

<p><b>OBJECTIVE</b>To study the correlation between the expansion with different volume and the contents of the b-FGF and EGF in the expanded skin.</p><p><b>METHODS</b>The piglets were used in the experiment,which were divided into 7 groups including the sham, the blank control,the experimental groups with inflation of 1/2 volume, 3/4 volume, full volume, 150% volume and 200% volume. When expansion was complete, b-FGF was measured using enzyme coagulate method. EGF was measured by radioimmunoassay. The data were analyzed statistically.</p><p><b>RESULTS</b>The contents of b-FGF and EGF in the expanded skin was significantly higher than normal skin (P < 0.05). The difference in contents of b-FGF and EGF between the over-expanded skin and normal skin was more significant (P < 0.01).</p><p><b>CONCLUSION</b>Expansion can lead to the increase of b-FGF and EGF contents in the expanded skin.The biological effects may be relative to epidermal hyperplasia and angiogenesis of the expanded skin.</p>