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Study on molecular cytogenetic abnormalities in multiple myeloma / 中华血液学杂志
Chinese Journal of Hematology ; (12): 223-226, 2007.
Artículo en Chino | WPRIM | ID: wpr-328351
ABSTRACT
<p><b>OBJECTIVE</b>To explore the molecular cytogenetic abnormalities in multiple myeloma (MM).</p><p><b>METHODS</b>Bone marrow plasma cells from 23 previously untreated MM patients were purified by CD138 McAb magnetic cell sorting system, and a panel of probes for interphase fluorescence in situ hybridization were used to detect the 13q14 deletion, p53 deletion and IgH gene translocation in the sorted MM cells.</p><p><b>RESULTS</b>Among 23 MM patients, 13q14 deletion was observed in 10 (43.5%) cases, with the positive rate of 13q14 deleted cells ranged from 79% to 96%; 14q32 translocation was observed in 11 (47.8%) cases; 13q14 deletion and 14q32 translocation were simultaneously observed in 7 (30.4%) cases; and p53 deletion was observed in none of the 23 cases.</p><p><b>CONCLUSION</b>The frequency of 13q14 deletion and IgH gene translocation in multiple myeloma are high; and the relationship between 13q14 deletion, IgH gene translocation and prognosis is worth further investigating.</p>
Asunto(s)
Texto completo: Disponible Índice: WPRIM (Pacífico Occidental) Asunto principal: Células Plasmáticas / Reordenamiento Génico / Aberraciones Cromosómicas / Cadenas Pesadas de Inmunoglobulina / Hibridación Fluorescente in Situ / Eliminación de Gen / Genética / Mieloma Múltiple Tipo de estudio: Estudio pronóstico Límite: Anciano / Femenino / Humanos / Masculino Idioma: Chino Revista: Chinese Journal of Hematology Año: 2007 Tipo del documento: Artículo

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Texto completo: Disponible Índice: WPRIM (Pacífico Occidental) Asunto principal: Células Plasmáticas / Reordenamiento Génico / Aberraciones Cromosómicas / Cadenas Pesadas de Inmunoglobulina / Hibridación Fluorescente in Situ / Eliminación de Gen / Genética / Mieloma Múltiple Tipo de estudio: Estudio pronóstico Límite: Anciano / Femenino / Humanos / Masculino Idioma: Chino Revista: Chinese Journal of Hematology Año: 2007 Tipo del documento: Artículo