Allogeneic hematopoietic stem cell transplantation for 16 patients with aplastic anemia / 中华血液学杂志
Chinese Journal of Hematology
;
(12): 78-82, 2007.
Artículo
en Chino
| WPRIM
| ID: wpr-328371
ABSTRACT
<p><b>OBJECTIVE</b>To evaluate the efficacy of allogeneic hematopoietic stem cell transplantation (allo-HSCT) for aplastic anemia (AA).</p><p><b>METHODS</b>Twelve patients with severe AA (SAA) and 4 with chronic AA (CAA) received allo- HSCT. The effectiveness and complication were analyzed retrospectively.</p><p><b>RESULTS</b>Hematopoiesis reconstitution was achieved 14 patients (87.50%). The median time of neutrophils reached to 0.5 x 10(9)/L and platelets reached to 20 x 10(9)/L were 14 (11 - 16) and 14 (10 - 33) days, respectively. Six cases developed grade I - II acute graft-versus-host disease (aGVHD), chronic local GVHD occurred in 2 patients. Graft rejection occurred in 3 cases. Thirteen cases survived with a median of 10 (0.5 - 84) months at the end of follow-up. Three cases died of un-engraftment, graft rejection (GR) and interstitial pneumonia (IP) each.</p><p><b>CONCLUSION</b>Allo-HSCT is an effective therapy for patients with AA. Enhancing immunosuppressive treatment for conditioning and GVHD prophylaxis may reduce the incidence of GR and GVHD.</p>
Texto completo:
Disponible
Índice:
WPRIM (Pacífico Occidental)
Asunto principal:
Terapéutica
/
Trasplante Homólogo
/
Estudios Retrospectivos
/
Estudios de Seguimiento
/
Resultado del Tratamiento
/
Trasplante de Células Madre Hematopoyéticas
/
Rechazo de Injerto
/
Enfermedad Injerto contra Huésped
/
Anemia Aplásica
/
Métodos
Tipo de estudio:
Estudio observacional
/
Estudio pronóstico
Límite:
Adolescente
/
Adulto
/
Niño
/
Child, preschool
/
Femenino
/
Humanos
/
Masculino
Idioma:
Chino
Revista:
Chinese Journal of Hematology
Año:
2007
Tipo del documento:
Artículo
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