Association of Chinese medicine constitution susceptibility to diabetic nephropathy and transforming growth factor-β1 (T869C) gene polymorphism / 中国结合医学杂志
Chinese journal of integrative medicine
; (12): 680-684, 2011.
Article
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| ID: wpr-328433
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WPRO
ABSTRACT
<p><b>OBJECTIVE</b>To explore the association of Chinese medicine constitution susceptibility to diabetic nephropathy (DN) and transforming growth factor (TGF)-β1 (T869C) gene polymorphism.</p><p><b>METHODS</b>TGF-β1 gene polymorphism detected with polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) was screened for 180 DN cases and 180 type 2 diabetic mellitus (T2DM) cases without combined DN. Patients with DN were surveyed epidemiologically with constitution in the Chinese medicine questionnaire (CCMQ). Binary logistic regression analysis was utilized to study the correlation between nine types of Chinese medicine constitution and TGF-β1 (T869C) gene polymorphisms.</p><p><b>RESULTS</b>The DN group has a higher frequency of TGF-β1 (T869C) gene polymorphism than the T2DM group, and CC/CT genotypes than the T2DM group [CC, CT, TT (DN group): 88, 87, 5 (cases) versus (T2DM group) 71, 73, 36 (cases), P<0.05]. The phlegm-dampness constitution, damp-heat constitution, and blood stasis constitution have correlations with TGF-β1 (T869C) gene polymorphism.</p><p><b>CONCLUSION</b>Chinese medicine constitutions were associated with TGF-β1 (T869C) gene polymorphism, a potential predictor of susceptibility to DN in T2DM patients.</p>
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Asunto principal:
Constitución Corporal
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Modelos Logísticos
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Encuestas Epidemiológicas
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Predisposición Genética a la Enfermedad
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Polimorfismo de Nucleótido Simple
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Nefropatías Diabéticas
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Factor de Crecimiento Transformador beta1
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Genética
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Medicina Tradicional China
Tipo de estudio:
Diagnostic_studies
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Prognostic_studies
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Risk_factors_studies
Límite:
Aged
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Female
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Humans
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Male
Idioma:
En
Revista:
Chinese journal of integrative medicine
Año:
2011
Tipo del documento:
Article