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Changes of HLA-DR15 and immunoglobulin, T lymphocyte subsets in patients with aplastic anemia, myelodysplastic syndrome and their significance / 中国实验血液学杂志
Journal of Experimental Hematology ; (6): 111-115, 2010.
Artículo en Chino | WPRIM | ID: wpr-328562
ABSTRACT
The objective of this study was to detect the expression frequency of HLA-DR15 in patients with aplastic anemia (AA) and myelodysplastic syndrome (MDS), to investigate the relation of expression frequency with diseases and to analyze the relationship between immunoglobulin, T lymphocyte subsets and HLA-DR15. HLA-DR15 expression was detected by PCR-SSP; immunoglobulin was detected by immune turbidimetry; T cell subsets were detected by flow cytometry. The results showed that the expression rates of HLA-DR15 in AA and MDS as well as normal control groups were 78.6%, 63.2% and 24.6% respectively. The difference between AA, MDS and the normal control groups was statistically significant (p < 0.01). OR (odds ratios) values of AA and MDS groups were 11.262, 4.710 respectively. Compared with normal control group, expression rate of HLA-DR15 in hematologic malignancy group was not significantly different. The immunoglobulin level and abnormal T cell subsets in AA and MDS groups were statistically different between HLA-DR15 positive and negative groups (p > 0.05). It is concluded that the frequency of HLA-DR15 antigen in AA and MDS patients is significantly higher than that in normal control and hematologic malignancy group. OR value>1 showed a positive correlation between the diseases and HLA-DR15. HLA-DR15 is a susceptible gene in AA and MDS. The abnormalities of immunoglobulin level and ratios of T cell subsets in AA and MDS are common, but are not associated significantly with the expression of HLA-DR15.
Asunto(s)
Texto completo: Disponible Índice: WPRIM (Pacífico Occidental) Asunto principal: Síndromes Mielodisplásicos / Inmunoglobulinas / Prueba de Histocompatibilidad / Antígenos HLA-DR / Estudios de Casos y Controles / Subgrupos de Linfocitos T / Alergia e Inmunología / Subtipos Serológicos HLA-DR / Citometría de Flujo / Anemia Aplásica Tipo de estudio: Estudio observacional / Factores de riesgo Límite: Adolescente / Adulto / Anciano / Aged80 / Femenino / Humanos / Masculino Idioma: Chino Revista: Journal of Experimental Hematology Año: 2010 Tipo del documento: Artículo

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Texto completo: Disponible Índice: WPRIM (Pacífico Occidental) Asunto principal: Síndromes Mielodisplásicos / Inmunoglobulinas / Prueba de Histocompatibilidad / Antígenos HLA-DR / Estudios de Casos y Controles / Subgrupos de Linfocitos T / Alergia e Inmunología / Subtipos Serológicos HLA-DR / Citometría de Flujo / Anemia Aplásica Tipo de estudio: Estudio observacional / Factores de riesgo Límite: Adolescente / Adulto / Anciano / Aged80 / Femenino / Humanos / Masculino Idioma: Chino Revista: Journal of Experimental Hematology Año: 2010 Tipo del documento: Artículo