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The Effect of Curcumin and Human Adipose-derived Stromal Cells on Wound Healing of Lewis Rats
Journal of the Korean Society of Plastic and Reconstructive Surgeons ; : 110-114, 2010.
Artículo en Coreano | WPRIM | ID: wpr-32886
ABSTRACT

PURPOSE:

On this study, we investigated the effects of curcumin and adipose-derived stromal cells(ADSCs) in wound healing process, especially in the aspect of synergic effects when they were administrated simultaneously.

METHODS:

Curcumin(40mg/kg) and/or 1.0x10(6) ADSCs were applied to an 1.5x1.5cm-sized full thickness wound on the backs of male Lewis rats(n=5 in each group). In control group(n=5), saline was administrated instead of curcumin and ASCs. The wound size was followed by computer planimetry in 5, 7, and 14 days, and wounds were harvested for histological analysis in 7 and 14 days.

RESULTS:

The dimensions of wounds of curcumin, ADSCs, and curcumin-ADSCs group significantly decreased in 5, 7, 14 days compared with those of control group(p0.05). There were infiltration of more epithelization and more precisely organization of extracellular matrix in curcumin, ADSCs, and curcumin-ADSCs group compared with those of control group.

CONCLUSION:

The results suggest that curcumin and ADSCs have beneficial effects in the acceleration of wound healing. Although the simultaneous application of curcmin and ADSCs also has beneficial effects on wound healing, there are no significant synergic effects.
Asunto(s)

Texto completo: Disponible Índice: WPRIM (Pacífico Occidental) Asunto principal: Cicatrización de Heridas / Células del Estroma / Curcumina / Matriz Extracelular / Aceleración Límite: Animales / Humanos / Masculino Idioma: Coreano Revista: Journal of the Korean Society of Plastic and Reconstructive Surgeons Año: 2010 Tipo del documento: Artículo

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Texto completo: Disponible Índice: WPRIM (Pacífico Occidental) Asunto principal: Cicatrización de Heridas / Células del Estroma / Curcumina / Matriz Extracelular / Aceleración Límite: Animales / Humanos / Masculino Idioma: Coreano Revista: Journal of the Korean Society of Plastic and Reconstructive Surgeons Año: 2010 Tipo del documento: Artículo