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µ-opioid receptors in the central nucleus of the amygdala regulate food rather than water intake in rats / 南方医科大学学报
Journal of Southern Medical University ; (12): 1707-1712, 2014.
Artículo en Chino | WPRIM | ID: wpr-329215
ABSTRACT
<p><b>OBJECTIVE</b>To investigate the effect of µ-opioid receptors (µ-ORs) in the central nucleus of the amygdala (CeA) on feeding and drinking behaviors in rats and evaluate the role of glutamate signaling in opioid-mediated ingestive behaviors.</p><p><b>METHODS</b>Stainless steel cannulas were implanted in the unilateral CeA for microinjection of different doses of the selective µ-OR agonist DAMGO in satiated or water-deprived male SD rats. The subsequent food intake or water intake of the rats was measured at 60, 120, and 240 min after the injection. The rats receiving microinjections of naloxone (NTX, a nonselective opioid antagonist) or D-AP-5 (a selective N-methyl-D-aspartic acid-type glutamate receptor antagonist) prior to DAMGO microinjection were tested for food intake at 60, 120, and 240 min after the injections.</p><p><b>RESULTS</b>Injections of DAMGO (1-4 nmol in 0.5 µl) into the CeA significantly increased food intake in satiated rats, but did not affect water intake in rats with water deprivation. NTX (26.5 nmol in 0.5 µl) injected into the CeA antagonized DAMGO-induced feeding but D-AP-5 (6.3-25.4 nmol in 0.5 µl) injections did not produce such an effect.</p><p><b>CONCLUSION</b>µ-ORs in the CeA regulate food intake rather than water intake in rats, and the orexigenic role of µ-ORs is not dependent on the activation of the NMDA receptors in the CeA.</p>
Asunto(s)
Texto completo: Disponible Índice: WPRIM (Pacífico Occidental) Asunto principal: Farmacología / Fisiología / 2-Amino-5-fosfonovalerato / Ratas Sprague-Dawley / Receptores Opioides mu / Antagonistas de Aminoácidos Excitadores / Encefalina Ala(2)-MeFe(4)-Gli(5) / Ingestión de Líquidos / Ingestión de Alimentos / Núcleo Amigdalino Central Límite: Animales Idioma: Chino Revista: Journal of Southern Medical University Año: 2014 Tipo del documento: Artículo

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Texto completo: Disponible Índice: WPRIM (Pacífico Occidental) Asunto principal: Farmacología / Fisiología / 2-Amino-5-fosfonovalerato / Ratas Sprague-Dawley / Receptores Opioides mu / Antagonistas de Aminoácidos Excitadores / Encefalina Ala(2)-MeFe(4)-Gli(5) / Ingestión de Líquidos / Ingestión de Alimentos / Núcleo Amigdalino Central Límite: Animales Idioma: Chino Revista: Journal of Southern Medical University Año: 2014 Tipo del documento: Artículo