Study on gamma-synuclein gene in patients with idiopathic Parkinson's disease / 中华医学遗传学杂志
Chinese Journal of Medical Genetics
;
(6): 444-446, 2003.
Artículo
en Chino
| WPRIM
| ID: wpr-329438
ABSTRACT
<p><b>OBJECTIVE</b>To evaluate the relationship between idiopathic Parkinson's disease (PD) and two polymorphisms (C243G and A377T) of the gamma-synuclein gene in a Chinese Han population of Shanghai area.</p><p><b>METHODS</b>Polymorphic genotyping was performed with PCR-RPLP technique. Association analysis was carried out in 145 unrelated idiopathic PD patients and 184 age-matched healthy controls.</p><p><b>RESULTS</b>The authors failed to detect any distributional difference of the C243G and A377T polymorphisms of the gamma-synuclein gene between PD cases and control subjects, nor did they find any association.</p><p><b>CONCLUSION</b>These data do not support that gamma-synuclein gene C243G and A377T polymorphisms are involved in idiopathic PD onset in the Han population of Shanghai area.</p>
Texto completo:
Disponible
Índice:
WPRIM (Pacífico Occidental)
Asunto principal:
Enfermedad de Parkinson
/
Polimorfismo de Nucleótido Simple
/
Alelos
/
Sinucleínas
/
Gamma-Sinucleína
/
Frecuencia de los Genes
/
Genética
/
Genotipo
/
Proteínas del Tejido Nervioso
Límite:
Adulto
/
Anciano
/
Aged80
/
Humanos
Idioma:
Chino
Revista:
Chinese Journal of Medical Genetics
Año:
2003
Tipo del documento:
Artículo
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