Effect of piglitazone and metformin on retinol-binding protein-4 and adiponectin in patients with type 2 diabetes mellitus complicated with non-alcohol fatty acid liver diseases / 中国医学科学院学报
Acta Academiae Medicinae Sinicae
;
(6): 309-312, 2014.
Artículo
en Inglés
| WPRIM
| ID: wpr-329828
ABSTRACT
<p><b>OBJECTIVE</b>To compare the effects of piglitazone and metformin on retinol-binding protein-4 (RBP-4) and adiponcetin (APN) in patients with type 2 diabetes mellitus (T2DM) complicated with Non alcohol fatty acid liver disease (NAFLD).</p><p><b>METHODS</b>Totally 60 T2DM patients complicated with NAFLD were equally and randomly divided into pioglitazone group and metform group. The levels of biochemical indicators including body mass index (BMI), glucose hemoglobin A1C (GHbA1C), insulin resistance (HOMA-IR), fasting blood glucose (FBG), fasting insulin (FIns), and serum triglycerides (TG) as well as serum RBP-4 and APN level were measured pre-treatment and 12 weeks after treatments.</p><p><b>RESULTS</b>After 12 weeks of treaments, BMI, FBG, HOMA-IR, GHbA1C, FIns, and TG decreased (all P<0.05) in both piglitazone group and metform group. APN increased (all P<0.05) in both groups. RBP-4 decreased (P<0.05) in piglitazone group. Compare with the metform group, the levels of RBP-4, FIns ,and HOMA-IR decreased and BMI increased in piglitazone group (P<0.05).</p><p><b>CONCLUSION</b>Piglitazone is superior to metoform in decreasing RBP-4 level and HOMA-IR in patients with T2DM complicated with NAFLD.</p>
Texto completo:
Disponible
Índice:
WPRIM (Pacífico Occidental)
Asunto principal:
Farmacología
/
Sangre
/
Tiazolidinedionas
/
Diabetes Mellitus Tipo 2
/
Quimioterapia
/
Adiponectina
/
Proteínas Plasmáticas de Unión al Retinol
/
Hígado Graso
/
Metabolismo
/
Metformina
Límite:
Adulto
/
Anciano
/
Femenino
/
Humanos
/
Masculino
Idioma:
Inglés
Revista:
Acta Academiae Medicinae Sinicae
Año:
2014
Tipo del documento:
Artículo
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