Cis-CA1P inhibits tumor cell proliferation and prevents blood vessel formation / 中国应用生理学杂志
Chinese Journal of Applied Physiology
;
(6): 15-18, 2012.
Artículo
en Chino
| WPRIM
| ID: wpr-329958
ABSTRACT
<p><b>OBJECTIVE</b>To investigate the effects of cis-combretastatin-A1 phosphate (cis-CA1P) on tumor cell proliferation, and its effects on the blood vessel formations.</p><p><b>METHODS</b>MTT and IC50 values were used to assess the inhibitory effects of cis-CA1P on tumor cell proliferation. Chicken embryo chorioallantoic membrane and thoracic aorta annulations isolated from rats were used to investigate the effects of cis-CAIP on the blood vessel formation.</p><p><b>RESULTS</b>Cis-CA1P concentration-dependently inhibited the proliferations of several cancer cell lines, including human gastric carcinoma cell line MGC-803, human leukemic monocyte lymphoma cell line U937, human melanoma cell line A375, human colon cancer cell line HCT116, human breast carcinoma cell line MDA-MB-231, and human leukemia cell line K562. Cis-CAIP significantly decreased the formation of blood vessels in chicken embryo chorioallantoic membrane and in thoracic aorta annulations.</p><p><b>CONCLUSION</b>Cis-CA1P inhibits cancer cell proliferation and prevents blood vessel formation.</p>
Texto completo:
Disponible
Índice:
WPRIM (Pacífico Occidental)
Asunto principal:
Aorta
/
Farmacología
/
Fosfatos
/
Estilbenos
/
Técnicas In Vitro
/
Química
/
Línea Celular Tumoral
/
Membrana Corioalantoides
/
Proliferación Celular
/
Neovascularización Patológica
Límite:
Animales
/
Humanos
Idioma:
Chino
Revista:
Chinese Journal of Applied Physiology
Año:
2012
Tipo del documento:
Artículo
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