Observing the distribution of Annexin I and cPLA2 in the palatal process of mice by immunohistochemical staining / 华西口腔医学杂志

ABSTRACT

<p><b>OBJECTIVE</b>To observe the distribution of Annexin I and cytosolic phospholipose A2 (cPLA2) in the palatal process of dexamethasome teratogenerated mice.</p><p><b>METHODS</b>Cutting along the coronary plane of the heads of fetal mice to obtain palate in the 14th, 15th, 16th day of gestation by 10-week-old in-bred mice. The distribution of Annexin I and cPLA2 was checked by immunohistochemical staining.</p><p><b>RESULTS</b>During the fusing of the palatal processes, the staining of Annexin I and cPLA2 was positive in the epithelial and mesenchymal cells of the palatal process, and the intensity of staining changed with time.</p><p><b>CONCLUSION</b>Annexin I and cPLA2 can modulate the development of fetal palate to some extent, and they may be important mediators in the development of cleft palate induced by dexamethasone.</p>