An experimental study on PLGA carrier for oral tissue engineered mucosa by subcutaneous implantation in rabbits / 华西口腔医学杂志
West China Journal of Stomatology
;
(6): 362-365, 2004.
Artículo
en Chino
| WPRIM
| ID: wpr-330047
ABSTRACT
<p><b>OBJECTIVE</b>To look for the best carrier for cultivating oral tissue engineered mucosa.</p><p><b>METHODS</b>A series of membrane of scaffold materials of polycleclide-co-plycoclide (PLGA) were studied on their weight and biocompatibility after they had been implanted subcutaneously in rabbits for 1, 2, 3, 4 weeks respectively.</p><p><b>RESULTS</b>PLGA I , II, III degraded completely in rabbits after 2, 3, 4 weeks respectively. The other PLGA membrane degraded about 50% after 4 weeks. Histologically, the reactions of PLGA I, II, III with surrounding tissues were normal and membranes had a good biocompatibility.</p><p><b>CONCLUSION</b>The biodegrading rate of PLGA II is suitable for clinic practice. PLGA II was a promising carrier for oral tissue-engineered mucosa due to its excellent biocompatibility and biodegrading rate.</p>
Texto completo:
Disponible
Índice:
WPRIM (Pacífico Occidental)
Asunto principal:
Ácido Poliglicólico
/
Polímeros
/
Materiales Biocompatibles
/
Células Cultivadas
/
Ácido Láctico
/
Implantes Absorbibles
/
Biología Celular
/
Ingeniería de Tejidos
/
Metabolismo
/
Mucosa Bucal
Límite:
Animales
Idioma:
Chino
Revista:
West China Journal of Stomatology
Año:
2004
Tipo del documento:
Artículo
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