An experimental study on PLGA carrier for oral tissue engineered mucosa by subcutaneous implantation in rabbits / 华西口腔医学杂志

ABSTRACT

<p><b>OBJECTIVE</b>To look for the best carrier for cultivating oral tissue engineered mucosa.</p><p><b>METHODS</b>A series of membrane of scaffold materials of polycleclide-co-plycoclide (PLGA) were studied on their weight and biocompatibility after they had been implanted subcutaneously in rabbits for 1, 2, 3, 4 weeks respectively.</p><p><b>RESULTS</b>PLGA I , II, III degraded completely in rabbits after 2, 3, 4 weeks respectively. The other PLGA membrane degraded about 50% after 4 weeks. Histologically, the reactions of PLGA I, II, III with surrounding tissues were normal and membranes had a good biocompatibility.</p><p><b>CONCLUSION</b>The biodegrading rate of PLGA II is suitable for clinic practice. PLGA II was a promising carrier for oral tissue-engineered mucosa due to its excellent biocompatibility and biodegrading rate.</p>