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Study on the relationship between Fas expression and apoptosis in oral squamous cell carcinoma / 华西口腔医学杂志
West China Journal of Stomatology ; (6): 334-336, 2004.
Artículo en Chino | WPRIM | ID: wpr-330050
ABSTRACT
<p><b>OBJECTIVE</b>To investigate the relationship of Fas mRNA and protein expression and apoptosis in human oral squamous cell carcinoma.</p><p><b>METHODS</b>Northern blot and flow cytometry (TUNEL method) were used to detect the expression of Fas mRNA and Fas protein, cell cycle and apoptotic level in oral squamous cell carcinoma. The relationship between Fas gene expression and OSCC apoptosis was analyzed statistically.</p><p><b>RESULTS</b>Fas mRNA and protein could be detected in all five normal oral mucosa specimens. There was positive correlation between expression of Fas mRNA/protein and cell differentiation as well as apoptosis in OSCC (P < 0.005).</p><p><b>CONCLUSION</b>The expression of Fas gene was highly correlated with the differentiation and apoptosis in OSCC.</p>
Asunto(s)
Texto completo: Disponible Índice: WPRIM (Pacífico Occidental) Asunto principal: Neoplasias de la Boca / Carcinoma de Células Escamosas / Apoptosis / Receptor fas / Metabolismo Límite: Humanos Idioma: Chino Revista: West China Journal of Stomatology Año: 2004 Tipo del documento: Artículo

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Texto completo: Disponible Índice: WPRIM (Pacífico Occidental) Asunto principal: Neoplasias de la Boca / Carcinoma de Células Escamosas / Apoptosis / Receptor fas / Metabolismo Límite: Humanos Idioma: Chino Revista: West China Journal of Stomatology Año: 2004 Tipo del documento: Artículo