Effect of bombesin on IFN-induced fever and AVP content in brain of rats / 中国应用生理学杂志
Chinese Journal of Applied Physiology
;
(6): 300-303, 2004.
Artículo
en Chino
| WPRIM
| ID: wpr-330115
ABSTRACT
<p><b>AIM</b>To determine whether bombesin prevents IFN-alpha-induced fever and it's possible mechanism.</p><p><b>METHODS</b>Effects of BN on changes in body temperature and arginine vasopressin(AVP) content in the ventral septal area(VSA) and hypothalamus were measured in the rats following intracerebroventricular (ICV) injection of IFN-alpha.</p><p><b>RESULTS</b>(1) IFN-alpha produced a dose-dependent rise in colonic temperature simultaneously with increase in AVP content in the VSA in the rats. (2) BN produced a dose-dependent hypothermia and significantly elevated AVP content in the VSA in rats. (3) BN injected intracerebroventricularly at 30 min after IFN-alpha prevented the increase in colonic temperature which recovered to the control level as well as AVP content in the VSA in rats at 150 min.</p><p><b>CONCLUSION</b>AVP in the VSA may play a role in IFN-alpha-induced fever. AVP in the VSA may play a partial role in the BN antipyretic action and hypothermic action.</p>
Texto completo:
Disponible
Índice:
WPRIM (Pacífico Occidental)
Asunto principal:
Farmacología
/
Regulación de la Temperatura Corporal
/
Encéfalo
/
Arginina Vasopresina
/
Bombesina
/
Interferón-alfa
/
Ratas Wistar
/
Fiebre
/
Metabolismo
Límite:
Animales
Idioma:
Chino
Revista:
Chinese Journal of Applied Physiology
Año:
2004
Tipo del documento:
Artículo
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