The changes of estrogen receptor (ER) and progesterone receptor (PR) mRNAs in endometrium with endometriosis / 中国应用生理学杂志

ABSTRACT

<p><b>AIM</b>To explore the expression of ER and PR mRNAs in endometrium with endometriosis.</p><p><b>METHODS</b>The rat model of endometriosis was established, and the expression of ER, PR mRNAs in the endometrium was examined by reverse transcription-polymerase chain reaction (RT-PCR).</p><p><b>RESULTS</b>The expression of ER and PR mRNAs in ectopic endometrium was significantly lower than that in eutopic and normal endometrium (P < 0.01). But no difference was observed between eutopic and normal endometrium (P > 0.05). Ratio of ER/PR mRNA in ectopic endometrium was larger than that in eutopic and in normal endometrium (P < 0.01).</p><p><b>CONCLUSION</b>The result illuminates that the increased ER plays a vital role in the onset of endometriosis.</p>