Network pharmacology study of mechanism on xuesaitong injection against retinal vein occlusion / 中国中药杂志
China Journal of Chinese Materia Medica
;
(24): 2322-2325, 2014.
Artículo
en Chino
| WPRIM
| ID: wpr-330297
ABSTRACT
Retinal vein occlusion (RVO) is a common clinical disease causing vision loss. Risk factors such as diabetes, atherosclerosis are closely associated with RVO. Xuesaitong injection is used extensively in clinical treatment of RVO, however the mechanism is still unclear. In this study, we investigated the protective effect of Xuesaitong injection on RVO rat model. Using a compound-target network of Xuesaitong on anti-RVO constructed by literature mining, we aim to elucidate the multi-compound, multi-target effect of Xuesaitong injection. Fifteen potential targets of Xuesaitong injection associated with inflammation, angiogenesis, apoptosis, and coagulation were identified in this study. VEGF, IL-1beta and IL-6, three important targets in the compound-target network were further experimentally validated. This study provided experimental evidence for Xuesaitong injection being effective in treating RVO and a network view on its anti-RVO mode of action through a multi-compound and multiple-target mechanism.
Texto completo:
Disponible
Índice:
WPRIM (Pacífico Occidental)
Asunto principal:
Oclusión de la Vena Retiniana
/
Medicamentos Herbarios Chinos
/
Interleucina-6
/
Ratas Sprague-Dawley
/
Quimioterapia
/
Redes Reguladoras de Genes
/
Genética
/
Metabolismo
Tipo de estudio:
Estudio pronóstico
/
Factores de riesgo
Límite:
Animales
/
Humanos
/
Masculino
Idioma:
Chino
Revista:
China Journal of Chinese Materia Medica
Año:
2014
Tipo del documento:
Artículo
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