Expression of pituitary tumor transforming gene in human renal clear cell carcinoma and its significance / 南方医科大学学报

ABSTRACT

<p><b>OBJECTIVE</b>To explore the expression of pituitary tumor transforming gene (PTTG) in human renal clear cell carcinoma (RCCC) and its significance.</p><p><b>METHODS</b>PTTG protein expression was detected by immunohistochemistry in 87 RCCC and 45 paired normal renal tissues.</p><p><b>RESULTS</b>PTTG was expressed differentially between the normal renal and RCCC tissues. Compared with normal tissues, the primary RCCC tissues showed significantly increased expression of PTTG protein (P<0.001). The positive rate of PTTG protein was positively correlated to the tumor size, clinical stage and Fuhrman grade of RCCC (P=0.009, 0.008 and 0.035, respectively).</p><p><b>CONCLUSION</b>Increased PTTG protein expression may be involved in the carcinogenesis and progression of RCCC.</p>