Your browser doesn't support javascript.
loading
Dynamic expression of bFGF and TGFbeta2 in glomus cell grafts of carotid body in rat model of Parkinson disease / 华中科技大学学报(医学)(英德文版)
Journal of Huazhong University of Science and Technology (Medical Sciences) ; (6): 380-395, 2003.
Artículo en Inglés | WPRIM | ID: wpr-330900
ABSTRACT
To investigate the changes in the expression of basic fibroblast growth factor (bFGF) and transforming growth factor beta 2 (TGFbeta2) in glomus cell grafts of carotid body in the rat model of 6-hydroxydopamine-induced Parkinson disease, immunohistochemical staining of bFGF and TGFbeta2 in the sections of striate body was done on the 2nd, 4th and 12th week after transplantation. The results showed that on the 2nd week after transplantation, bFGF and TGFbeta2 were not detectable in the glumous cell grafts. On the 4th week after graft, bFGF and TGFbeta2 immunoreactivity was increased within the grafts and at the graft-host interface but was restricted only to astrocytes. In the striatum surrounding the graft, bFGF was expressed persistently, while TGFbeta2 showed transient expression. It was suggested that the transient expression of TGFbeta2 was likely due more to the trauma imposed by the graft procedure than to an intrinsic. The deficiency in astrocytic bFGF early after graft may be responsible for the poor survival of grafted glomus cells of carotid body.
Asunto(s)
Texto completo: Disponible Índice: WPRIM (Pacífico Occidental) Asunto principal: Enfermedad de Parkinson / Cirugía General / Trasplante / Trasplante Homólogo / Cuerpo Carotídeo / Factor 2 de Crecimiento de Fibroblastos / Factor de Crecimiento Transformador beta / Biología Celular / Factor de Crecimiento Transformador beta2 / Genética Tipo de estudio: Estudio pronóstico Límite: Animales Idioma: Inglés Revista: Journal of Huazhong University of Science and Technology (Medical Sciences) Año: 2003 Tipo del documento: Artículo

Similares

MEDLINE

...
LILACS

LIS

Texto completo: Disponible Índice: WPRIM (Pacífico Occidental) Asunto principal: Enfermedad de Parkinson / Cirugía General / Trasplante / Trasplante Homólogo / Cuerpo Carotídeo / Factor 2 de Crecimiento de Fibroblastos / Factor de Crecimiento Transformador beta / Biología Celular / Factor de Crecimiento Transformador beta2 / Genética Tipo de estudio: Estudio pronóstico Límite: Animales Idioma: Inglés Revista: Journal of Huazhong University of Science and Technology (Medical Sciences) Año: 2003 Tipo del documento: Artículo