Expression of angiopoietin-2 gene in non-small cell lung cancer / 华中科技大学学报(医学)(英德文版)
Journal of Huazhong University of Science and Technology (Medical Sciences)
;
(6): 362-364, 2003.
Artículo
en Inglés
| WPRIM
| ID: wpr-330905
ABSTRACT
To study the expression of Angiopoietin 2 (Ang-2) gene and its relationship with clinical pathological characteristics of non-small cell lung cancer (NSCLC), expression of the Ang-2 mRNA was evaluated by employing reverse transcription polymerase chain reaction (RT-PCR) in cancerous tissues and paired adjacent noncancerous tissues from 52 patients. The expression of Ang-2 gene was detected in a significantly greater proportion of cancerous tissues (80.8%) than paired adjacent noncancerous tissues (53.8%, P<0.01). No significant relationship was found between Ang-2 gene expression and patients' age, sex, histology of tumors, differentiation and TNM stages (P>0.05). It is concluded that the up-regulation of Ang-2 gene may play a role in the pathway of NSCLC carcinogenesis and Ang-2 may be used as a potential therapeutic agent for lung cancer.
Texto completo:
Disponible
Índice:
WPRIM (Pacífico Occidental)
Asunto principal:
Patología
/
ARN Mensajero
/
Carcinoma de Células Escamosas
/
Adenocarcinoma
/
Carcinoma de Pulmón de Células no Pequeñas
/
Reacción en Cadena de la Polimerasa de Transcriptasa Inversa
/
Angiopoyetina 2
/
Genética
/
Neoplasias Pulmonares
/
Metabolismo
Límite:
Adulto
/
Anciano
/
Femenino
/
Humanos
/
Masculino
Idioma:
Inglés
Revista:
Journal of Huazhong University of Science and Technology (Medical Sciences)
Año:
2003
Tipo del documento:
Artículo
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