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The effects of Ligustrazine on the expression of bFGF and bFGFR in bone marrow in radiation injured mice / 华中科技大学学报(医学)(英德文版)
Journal of Huazhong University of Science and Technology (Medical Sciences) ; (6): 348-351, 2003.
Artículo en Inglés | WPRIM | ID: wpr-330909
ABSTRACT
To study the expression of the bFGF and its receptor in the mouse bone marrow by treatment with acute radioactive injury and Ligustrazine, 56 mice were divided into 3 groups normal group, radiation-injured group and Ligustrazine group. After irradiation by 6.0 Gy 60Co gamma-ray, each mouse was orally given 0.1 ml Ligustrazine twice a day for 13 days in Ligustrazine group, and each mouse in radiation injured group was orally given equal amount of saline. On the 3rd, 7th, 14th day after irradiation, bone marrow mono-nuclear cells (BMMNC) were counted, and the expression levels of bPGF and bFGFR in bone marrow were evaluated by immunohistochemistry and flow cytometry analysis respectively. On the 3rd, 7th, 14th day after irradiation, expression of bFGF in bone marrow were significantly lower than in normal group (P<0.05 or P<0.01). Expressions of bFGF and bFGFR were much higher in Ligustrazine treated group than that in the control group (P<0.05 or P<0.01). Ligustrazine potentiate the expression of bFGF and bFGFR in bone marrow MNC to recover the bone marrow hematopoiesis inductive microenvironment, which is one of the mechanisms by which Ligustrazine rebuild the bone marrow hematopoiesis after acute radioactive injury.
Asunto(s)
Texto completo: Disponible Índice: WPRIM (Pacífico Occidental) Asunto principal: Farmacología / Pirazinas / Traumatismos Experimentales por Radiación / Protectores contra Radiación / Células de la Médula Ósea / Factor 2 de Crecimiento de Fibroblastos / Receptores de Factores de Crecimiento de Fibroblastos / Hematopoyesis / Metabolismo Límite: Animales Idioma: Inglés Revista: Journal of Huazhong University of Science and Technology (Medical Sciences) Año: 2003 Tipo del documento: Artículo

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Texto completo: Disponible Índice: WPRIM (Pacífico Occidental) Asunto principal: Farmacología / Pirazinas / Traumatismos Experimentales por Radiación / Protectores contra Radiación / Células de la Médula Ósea / Factor 2 de Crecimiento de Fibroblastos / Receptores de Factores de Crecimiento de Fibroblastos / Hematopoyesis / Metabolismo Límite: Animales Idioma: Inglés Revista: Journal of Huazhong University of Science and Technology (Medical Sciences) Año: 2003 Tipo del documento: Artículo