Correlation between expression of matrix metalloproteinase-2 and angiogenesis in esophageal carcinoma / 中华肿瘤杂志
Chinese Journal of Oncology
;
(12): 96-98, 2005.
Artículo
en Chino
| WPRIM
| ID: wpr-331219
ABSTRACT
<p><b>OBJECTIVE</b>To study expression of MMP-2 in relation to microvessel density (MVD) in esophageal carcinoma.</p><p><b>METHODS</b>Forty-eight specimens of esophageal carcinoma (Ec) and 17 specimens of grade II + III epithelial dysplasia (Dy) close to the tumor and 12 specimens of normal tissue (Nt) along the incisional margin were examined by S-P immunohistochemical staining with anti-MMP-2 monoclonal antibody. An anti-CD34 monoclonal antibody was used to show MVD.</p><p><b>RESULTS</b>MMP-2 expression in Ec was remarkably higher than that in Dy, which was higher than that in Nt. MMP-2 expression in Ec and Dy was significantly correlated with MVD in the tumor and nearby tissue. MMP-2 expression and MVD in Ec significantly associated with lymph node metastasis.</p><p><b>CONCLUSION</b>Expression of MMP-2 plays an important role in angiogenesis and lymph node metastasis of esophageal cancer.</p>
Texto completo:
Disponible
Índice:
WPRIM (Pacífico Occidental)
Asunto principal:
Patología
/
Neoplasias Esofágicas
/
Carcinoma de Células Escamosas
/
Metaloproteinasa 2 de la Matriz
/
Metástasis Linfática
/
Metabolismo
/
Microcirculación
/
Neovascularización Patológica
Límite:
Femenino
/
Humanos
/
Masculino
Idioma:
Chino
Revista:
Chinese Journal of Oncology
Año:
2005
Tipo del documento:
Artículo
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