Apoptosis-related gene expression and its clinical significance of human osteosarcoma / 中华肿瘤杂志
Chinese Journal of Oncology
;
(12): 678-681, 2004.
Artículo
en Chino
| WPRIM
| ID: wpr-331233
ABSTRACT
<p><b>OBJECTIVE</b>To explore the prognostic markers in osteosarcoma.</p><p><b>METHODS</b>Expressions of p53, c-myc, bcl-2 and apoptosis index (AI) in 28 osteosarcoma specimens were detected by ABC immunohistochemistry and terminal deoxynucleotidyl transferase (TdT)-mediated dUTP-digoxigenin nick end labelling (TUNEL). The relationship between gene expression and apoptosis, and their correlations with pathologic classification and prognostic factors were analyzed.</p><p><b>RESULTS</b>There was negative correlation between the expressions of p53, c-myc, bcl-2 protein and AI, which was closely related to the long term survival of patients but was not related to pathologic types of the tumor.</p><p><b>CONCLUSION</b>The expressions of p53, c-myc, bcl-2 protein and AI can be used as an index for predicting the progression and prognosis of osteosarcoma.</p>
Texto completo:
Disponible
Índice:
WPRIM (Pacífico Occidental)
Asunto principal:
Patología
/
Pronóstico
/
Neoplasias Óseas
/
Biomarcadores de Tumor
/
Osteosarcoma
/
Tasa de Supervivencia
/
Estudios de Seguimiento
/
Proteína p53 Supresora de Tumor
/
Apoptosis
/
Progresión de la Enfermedad
Tipo de estudio:
Estudio observacional
/
Estudio pronóstico
Límite:
Adolescente
/
Adulto
/
Femenino
/
Humanos
/
Masculino
Idioma:
Chino
Revista:
Chinese Journal of Oncology
Año:
2004
Tipo del documento:
Artículo
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