Regulation of miR-24 on vascular endothelial cell function and its role in the development of cardiovascular disease / 生理学报

ABSTRACT

microRNA-24 (miR-24) belongs to miR-23~27~24 cluster. It is highly expressed in vascular endothelial cells (VECs), and plays an important role in the regulation of VECs specific gene expression. Recent studies indicate that miR-24 is involved in the regulation of VECs function such as proliferation, apoptosis, angiopoiesis, inflammation, and differentiation. The dysregulation of miR-24 is associated with dysfunction or even damage of VECs, and contributes to the development of cardiovascular disease. In this review, we summarized the molecular mechanisms of miR-24 in regulating VECs function, and its role and importance during the development of cardiovascular disease.