Clinical effect of shenbing mistura combined with glucocorticoid on recurrent nephrotic syndrome in children and levels of interleukin-6 and tumor necrosis factor-alpha in blood and urine / 中国中西医结合杂志
Chinese Journal of Integrated Traditional and Western Medicine
;
(12): 892-895, 2006.
Artículo
en Chino
| WPRIM
| ID: wpr-331957
ABSTRACT
<p><b>OBJECTIVE</b>To study the effect of Shenbing Mistura (SM) combined with glucocorticoid on recurrent nephrotic syndrome (RNS) in children and levels of interleukin-6 (IL-6) and tumor necrosis factor-alpha (TNF-alpha) in blood and urine.</p><p><b>METHODS</b>The treatment group was treated with SM plus glucocorticoid, the control group with glucocorticoid alone, and a healthy control group was adopted, 30 cases in each group. The clinical effect and recurrence rate were observed, and levels of IL-6 and TNF-alpha in blood and urine were determined before treatment and at the 4th, 8th, 12th week after treatment.</p><p><b>RESULTS</b>Significant difference of IL-6 and TNF-alpha levels in blood and urine was found in either the pre- and post- treatment auto-control of both the treatment group and control group, or in the inter-group comparison of them (P < 0.01); clinical effect also showed remarkable difference between the two groups (P < 0.01). Furthermore, the recurrence rate of the treatment group was lower than that of the control group showed by a 18-month follow-up (P < 0.01).</p><p><b>CONCLUSION</b>SM combined with glucocorticoid could significantly reduce the recurrence rate and elevate the clinical effect in children with RNS, it could also lower the levels of IL-6 and TNF-alpha in patients' blood and urine.</p>
Texto completo:
Disponible
Índice:
WPRIM (Pacífico Occidental)
Asunto principal:
Patología
/
Recurrencia
/
Orina
/
Sangre
/
Prednisona
/
Medicamentos Herbarios Chinos
/
Estudios de Seguimiento
/
Interleucina-6
/
Factor de Necrosis Tumoral alfa
/
Resultado del Tratamiento
Tipo de estudio:
Estudio observacional
/
Estudio pronóstico
Límite:
Adulto
/
Niño
/
Child, preschool
/
Femenino
/
Humanos
/
Masculino
Idioma:
Chino
Revista:
Chinese Journal of Integrated Traditional and Western Medicine
Año:
2006
Tipo del documento:
Artículo
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