Expression of c-fos, OPG, OPGL in rabbit mandibular distraction osteogenesis zone / 浙江大学学报·医学版

ABSTRACT

<p><b>OBJECTIVE</b>To evaluate the possible signal transduction mechanism of the mechanical stress induced by the distraction procedure in osteocytes.</p><p><b>METHODS</b>An animal model of mandibular distraction osteogenesis in rabbits was established. The expressions of c-fos, OPG and OPGL were detected by ultrasensitive S-P immunohistochemical method.</p><p><b>RESULT</b>At 4 and 8 days after distraction, distraction zone showed strong positive staining of c-fos, which were apparently higher than that in distraction zone of 2, 4 and 6 weeks after consolidation. At 4 and 8 days after distraction and 2 weeks after consolidation, the expression of OPG was strong, and then wore off gradually at 4 and 6 weeks after consolidation. Weak signals of OPGL could be detected at 6 weeks after consolidation only.</p><p><b>CONCLUSION</b>c-fos, OPG and OPGL are important regulators in distraction osteogenesis. c-fos is interrelated with the mechanical stress induced by the distraction procedure closely, OPG promotes new bone formation, while OPGL plays a more active role in bone remodeling.</p>