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Using 1H-MRS to evaluate the effects of warm ischemia reperfusion injury on the regeneration of hepatic cells in orthotopic transplanted livers in rats / 中华肝脏病杂志
Chinese Journal of Hepatology ; (12): 274-278, 2008.
Artículo en Chino | WPRIM | ID: wpr-332258
ABSTRACT
<p><b>OBJECTIVE</b>To investigate the prognostic value of proton magnetic resonance spectroscopy (1H-MRS) in the study of warm ischemia reperfusion injury to the regeneration of hepatic cells of the livers following their orthotopic transplantation in rats.</p><p><b>METHODS</b>A rat orthotopic liver transplantation (OLT) model with warm ischemia, the experimental group, was established and the same was done with a control group but without warm ischemia of the livers. They were studied at 6 time points (6 hours, 1, 3, 7, 14, and 30 days after OLT). All rats took axial T1 weighted and T2 weighted imaging scans and 1H MR spectroscopies.</p><p><b>RESULTS</b>The positive rate of proliferating cell nuclear antigen (PCNA) and the mean peak choline/water ratio in the experimental group were significantly higher than those in the control group and the peak choline /water ratio had a positive correlation with the positive rate of PCNA. Serum ALT and AST increased significantly after OLT, especially during the 6 hour to 3day period. The levels of ALT and AST were markedly higher in the experimental group compared to the control group.</p><p><b>CONCLUSION</b>Warm ischemia reperfusion injury of OLT has a significant effect on the regeneration of hepatic cells, and the choline peak of 1H-MRS can be used to evaluate the regeneration of hepatic cells non-invasively.</p>
Asunto(s)
Texto completo: Disponible Índice: WPRIM (Pacífico Occidental) Asunto principal: Espectroscopía de Resonancia Magnética / Daño por Reperfusión / Trasplante de Hígado / Ratas Sprague-Dawley / Hepatocitos / Biología Celular / Diagnóstico / Isquemia Tibia / Supervivencia de Injerto / Regeneración Hepática Tipo de estudio: Estudio diagnóstico / Estudio pronóstico Límite: Animales Idioma: Chino Revista: Chinese Journal of Hepatology Año: 2008 Tipo del documento: Artículo

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Texto completo: Disponible Índice: WPRIM (Pacífico Occidental) Asunto principal: Espectroscopía de Resonancia Magnética / Daño por Reperfusión / Trasplante de Hígado / Ratas Sprague-Dawley / Hepatocitos / Biología Celular / Diagnóstico / Isquemia Tibia / Supervivencia de Injerto / Regeneración Hepática Tipo de estudio: Estudio diagnóstico / Estudio pronóstico Límite: Animales Idioma: Chino Revista: Chinese Journal of Hepatology Año: 2008 Tipo del documento: Artículo