Inhibitory effect of resveratrol against enterovirus type 71 in vitro / 南方医科大学学报

ABSTRACT

<p><b>OBJECTIVE</b>To observe the inhibitory effect of resveratrol against the cytopathogenicity of enterovirus type 71.</p><p><b>METHODS</b>The cytotoxicity of resveratrol on Vero cells was detected using cell counting kit-8 (CCK-8). The antiviral activity of resveratrol in different stages of infection, with ribavirin as the control, was evaluated by determining the virus inhibition rate, medium effective concentration (IC(50)), and selection index (SI).</p><p><b>RESULTS</b>Resveratrol was nonpoisonous to Vero cells with an median toxic concentration (TC50) of 307.6 mmol/L. Resveratrol produced an obvious inhibitory effect against enterovirus type 71 only before the cell infection by the virus (IC(50)=20.2 mmol/L , SI=15.2), and once the cells were infected, resveratrol no longer had such antiviral effect.</p><p><b>CONCLUSIONS</b>Resveratrol may offer some protection against enterovirus type 71 in vitro.</p>