Correlation of Eps8 with proliferation, metastasis and prognosis of malignant tumors / 中国实验血液学杂志
Journal of Experimental Hematology
;
(6): 493-497, 2013.
Artículo
en Chino
| WPRIM
| ID: wpr-332750
ABSTRACT
Epidermal growth factor receptor pathway substrate 8 (Eps8) is one of crucial kinase substrates for the epidermal growth factor receptors. Eps8 is related to mitosis and differentiation of normal cells. In recent years, it has been demonstrated that Eps8 involves in proliferation, metastasis and prognosis of many malignant tumors. Experiments have shown that Eps8 involves in Ras-Rac pathway of EGFR signaling by forming Eps8-Abi1-Sos1 tri-complex or participates in endocytosis mediated by rab5. Furthermore, Eps8 has also been found to regulate cell cycle. In conclusion, it may become a monitor and a new target for the treatment of malignant tumors. This review briefly introduces molecular structure and physiological function of Eps8, focusing on its function and molecular mechanism in proliferation, metastasis and prognosis of malignant tumors.
Texto completo:
Disponible
Índice:
WPRIM (Pacífico Occidental)
Asunto principal:
Patología
/
Pronóstico
/
Proteínas Adaptadoras Transductoras de Señales
/
Metabolismo
/
Metástasis de la Neoplasia
/
Neoplasias
Tipo de estudio:
Estudio pronóstico
Límite:
Humanos
Idioma:
Chino
Revista:
Journal of Experimental Hematology
Año:
2013
Tipo del documento:
Artículo
Similares
MEDLINE
...
LILACS
LIS