Anti-infective reconstituted bone xenograft used for primary bone grafting to repair contaminated defect in the radius in dogs / 中华创伤杂志(英文版)

ABSTRACT

<p><b>OBJECTIVE</b>To investigate the effect of anti-infective reconstituted bone xenograft as a primary graft to repair a segmental with severe contamination.</p><p><b>METHODS</b>A canine model of contaminated defect of 1.5 cm in size in the radius was used, in which anti-infective reconstituted bone xenograft or reconstituted bone xenograft was implanted as a primary graft followed by internal fixation. The effectiveness of the two grafting materials in repairing a contaminated segmental defect was compared.</p><p><b>RESULTS</b>The animals which had received implant of anti-infective reconstituted bone xenograft should largely healed defects 6 months after operation while the defects implanted with reconstituted bone xenograft remained unrepaired with bone infection.</p><p><b>CONCLUSIONS</b>Besides its strong osteoinductive and osteoconductive activity, anti-infective reconstituted bone xenograft is highly antibacterial and can be used as a primary graft to repair the severely contaminated segmental defect.</p>