Effects of Ginsenoside Rb1 on proliferation of Schwann cells in culture / 中华创伤杂志(英文版)
Chinese Journal of Traumatology
;
(6): 365-368, 2002.
Artículo
en Inglés
| WPRIM
| ID: wpr-332931
ABSTRACT
<p><b>OBJECTIVE</b>To investigate the effects of Ginsenoside Rb(1) on the proliferation of Schwann cells in culture.</p><p><b>METHODS</b>Applying MTT assay and Thymidine incorporation assay, the effects of Ginsenoside Rb(1) on the proliferation of Schwann cells isolated from the sciatic nerve of adult rat were studied.</p><p><b>RESULTS</b>Ginsenoside Rb(1) (10 microg/ml) significantly induced Schwann cell proliferation, the effect was similar to NGF (50 microg/ml). At high concentrations of Ginsenoside Rb(1) (1 mg/ml), the proliferation of Schwann cells was significantly inhibited.</p><p><b>CONCLUSIONS</b>Ginsenoside Rb(1) at the optimal concentrations is found to be effective in inducing the proliferation of Schwann cells, but at higher concentrations the drug is cytotoxic for Schwann cells.</p>
Texto completo:
Disponible
Índice:
WPRIM (Pacífico Occidental)
Asunto principal:
Farmacología
/
Fisiología
/
Ratas Endogámicas
/
Células de Schwann
/
Nervio Ciático
/
Inmunohistoquímica
/
División Celular
/
Células Cultivadas
/
Probabilidad
/
Sensibilidad y Especificidad
Tipo de estudio:
Estudio diagnóstico
Límite:
Animales
Idioma:
Inglés
Revista:
Chinese Journal of Traumatology
Año:
2002
Tipo del documento:
Artículo
Similares
MEDLINE
...
LILACS
LIS