Preliminary study on nasal spray of interferon alpha-2b used for prevention of rubella and measles virus infections / 中华实验和临床病毒学杂志
Chinese Journal of Experimental and Clinical Virology
;
(6): 220-222, 2005.
Artículo
en Chino
| WPRIM
| ID: wpr-333037
ABSTRACT
<p><b>OBJECTIVE</b>To evaluate the efficacy of the interferon alpha-2b nasal spray in prevention of rubella and measles virus infections.</p><p><b>METHODS</b>The properly selected volunteer groups have been divided into interferon alpha-2b experimental and control group. The experimental group received interferon alpha-2b treatment by nasal spray for 2 days before the immunization, then both groups were challenged with rubella and measles attenuated live vaccine respectively through nasal spray. The sera from pre-immunization and 21 and 28 days after immunization were collected to test the IgG antibody titers. The influence on the viral antibody titer reflects the viral preventive effect by interferon alpha-2b.</p><p><b>RESULTS</b>The antibody titer difference of measles virus between experimental and control group was 1.26 (21 day) and 2.96 (28 day), there were statistically difference between them; the difference of rubella virus was 0.95 (21 day) and 0.37 (28 day), but there were no statistically differences found.</p><p><b>CONCLUSION</b>The preliminary results showed that the interferon alpha-2b can be used as prevention method for measles and rubella viral infections.</p>
Texto completo:
Disponible
Índice:
WPRIM (Pacífico Occidental)
Asunto principal:
Antivirales
/
Rubéola (Sarampión Alemán)
/
Virus de la Rubéola
/
Virología
/
Sangre
/
Proteínas Recombinantes
/
Administración Intranasal
/
Vacuna Antisarampión
/
Vacuna contra la Rubéola
/
Vacunas Atenuadas
Límite:
Adulto
/
Femenino
/
Humanos
/
Masculino
Idioma:
Chino
Revista:
Chinese Journal of Experimental and Clinical Virology
Año:
2005
Tipo del documento:
Artículo
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