The influence of mitochondrial complex inhibition on neuronal ion channel and neurotransmitter release / 生理学报
Acta Physiologica Sinica
; (6): 713-720, 2012.
Article
en En
| WPRIM
| ID: wpr-333149
Biblioteca responsable:
WPRO
ABSTRACT
Mitochondrial complex inhibition has been described in the pathophysiology of many neurodegenerative diseases, and the functional changes of neuron induced by mitochondrial complex inhibition and the mechanism are concerned. Neuronal function depends on action potentials and neurotransmitter release. Voltage dependent sodium/potassium ion channels mediate generation of neuron action potentials. And voltage dependent calcium ion channels are directly involved in the process of neurotransmitter release. The functional changes of those ion channels under some pathological conditions can induce neuron dysfunction, even death. Therefore, understanding the influence of mitochondrial complex inhibition on neuronal ion channels and neurotransmitter release is helpful to illuminate the pathophysiology of neurodegenerative diseases. This review will highlight recent progress in this field.
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Índice:
WPRIM
Asunto principal:
Fisiología
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Transporte Biológico
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Potenciales de Acción
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Canales de Calcio
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Canales de Potasio
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Canales de Sodio
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Transmisión Sináptica
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Neurotransmisores
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Enfermedades Neurodegenerativas
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Canales Iónicos
Límite:
Humans
Idioma:
En
Revista:
Acta Physiologica Sinica
Año:
2012
Tipo del documento:
Article